Dr. R. Krishna
About
Research Area
I am Dr. R. Krishna working as Professor in the department of bioinformatics, Pondicherry university Pondicherry. I have completed my MSc , M.Phil and Ph.D in (Bio-Physics) from the department of Crystallography and Biophysics, University of Madras, Guindy Campus, Chennai. I got trained in the Macromolecular Crystallography at Prof. M. Vijayan’s Lab, Molecular Biophysics Unit, Indian Institute of science (IISc) Bangalore . As a structural biologist our group is primarily working on protein structures (Protein- Protein interactions Protein- ligand interactions and Protein- DNA interactions) through computational approach. We are trying determine the proteins structures and their complexes which are involved in cancer (MurA ) and Tuberculosis ( KasA and KasB) through x-ray crystallography and in-silico method.
Notable & Recent Publications
"Manikandan Jayaraman, Lakshmanan Loganathan, Karthikeyan Muthusamy, Krishna Ramadas. Virtual screening assisted discovery of novel natural products to inhibit the catalytic mechanism of Mycobacterium tuberculosis InhA. Journal of Molecular Liquids. 2021 Apr 21. [IF: 6.165]"
"Sethi, G., Varghese, R. P., Lakra, A. K., Nayak, S. S., Krishna, R., & Hwang, J. H. (2024). Immunoinformatics and structural aided approach to develop multi-epitope based subunit vaccine against Mycobacterium tuberculosis. Nature Scientific Reports, 14(1), 15923. [IF: 3.8]."
Lakshmi T.Pragna, Amit Kumar, Veena Vijaykumar, Sakthivel Natarajan and Ramadas Krishna. Identification of natural allosteric inhibitor for Akt1 protein through computational approaches and in vitro evaluation” International Journal of Biological Macromolecules” 96 (2017): 200-213 [IF:7.7]
Wei Liang, Shuyu Miao, Bo Zhang, Shaohua He, Chengchao Shou, Panneer S. Manivel, Ramadas Krishna, Yiding Chen, Yuenian Eric Shi, Synuclein gamma protects Akt and mTOR and renders tumor resistance to Hsp90 disruption. Nature Oncogene (2014), 1-8 [I.F: 6.9]
Krishna R, Manjunath GP, Kumar P, Surolia A, Chandra NR, Muniyappa K, Vijayan M. Crystallographic identification of an ordered C-terminal domain and a second nucleotide-binding site in RecA: new insights into allostery, Nucl.Acids Res. 34: 2186-2195, 2006 [IF:16.7] cover page
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